Ethanol, 2,2'-(1,2-ethanediyldiimino)bis- → 1,2-Ethanediamine, N,N'-bis(2-chloroethyl)-, dihydrochloride

HRID 742387노트

반응식

HRID 742387 반응식
[Cl:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][Cl:10].OCCNCCNCCO>O=S(Cl)Cl>[ClH:1].[ClH:1].[Cl:1][CH2:2][CH2:3][NH:4][CH2:5][CH2:6][NH:7][CH2:8][CH2:9][Cl:10]

참가 물질

4

반응물 2

HCID 78179Ethanol, 2,2'-(1,2-ethanediyldiimino)bis-HCID 409899N,N'-Bis(2-chloroethyl)ethylenediamine

생성물 1

HCID 30474461,2-Ethanediamine, N,N'-bis(2-chloroethyl)-, dihydrochloride

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

실험 절차

N,N'-Bis(2-chloroethyl)ethylenediamine (BCE) A solution of N,N'-bis(2-hydroxyethyl)ethylenediamine (5.4 g, 0.036 mol) in SOCl2 (60 mL) was heated at 90° C. for 2 h, then stirred at room temperature for 24 h. Excess SOCl2 was then removed under reduced pressure, and the residue was triturated with isopropanol. Crystallisation from boiling isopropanol (800 mL) containing just enough water to dissolve the solids gave N,N'-bis(2-chloroethyl)ethylenediamine dihydrochloride (BCE.2HCl).

후처리

  1. customExcess SOCl2 was then removed under reduced pressure
  2. customthe residue was triturated with isopropanol
  3. customCrystallisation
  4. additioncontaining just enough water
  5. dissolutionto dissolve the solids

출처 및 근거

ORD 기록
ord-69d12510b9c14d179279c2e24e7d2eb4
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05554648

반응 노트

불러오는 중…