Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → 2-Pyridinyl-1,3-dioxolane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | 2-Pyridinecarboxaldehyde | HCID 14273 | — |
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Pyridinyl-1,3-dioxolane | HCID 79773 | 67% |
반응 단계
A mixture of 2-pyridinecarboxaldehyde (500 g, 4.67 mol), 561 mL of ethylene glycol, and 234 g of p-toluenesulfonic acid monohydrate in 5.8 L of toluene was heated to reflux while distilling (azeotropic) water formed during the reaction. The solvent was removed in vacuo and the residue was distilled to afford 475 g (67%) of 2-(1,3-dioxolan-2-yl)pyridine (Formula V: R1 =H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05554620 |
| 출처 데이터셋 | uspto-grants-1996_09 |
| ORD ID | ord-4e760bafeccd4509b7101e1c9747c6d6 |
| 출처 메모 | uspto-grants-1996_09 |