2-(4-n-Butylamino-3-nitrophenyl)benzoxazole → 2-(2-n-Butylaminoanilin-5-yl)benzoxazole

반응식

[CH2:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][C:7]=1[N+:21]([O-])=O)[CH2:2][CH2:3][CH3:4].[H][H]>[C].[Pd].O1CCCC1>[CH2:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)=[CH:8][C:7]=1[NH2:21])[CH2:2][CH2:3][CH3:4]

참가 물질

실험 절차

To a tetrahydrofuran solution (5 mL) of 2-(4-n-butylamino-3-nitrophenyl)benzoxazole (see Working Example 74-1) (353 mg, 1.13 mmol) was added 10% palladium-carbon (50 mg), a hydrogen atmosphere was substituted in the flask, and this was stirred at room temperature for 15 hours. After the reaction was complete, this was filtered through Celite and the filtrate was concentrated. The residue obtained was purified by silica gel column chromatography to yield the title compound (305 mg, 96% yield).