2-(4-Neopentylamino-3-nitrophenyl)benzoxazole → 2-(2-Neopentylaminoanilin-5-yl)benzoxazole

HRID 74257

반응식

HRID 74257 반응식
[CH2:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[O:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)=[CH:9][C:8]=1[N+:22]([O-])=O)[C:2]([CH3:5])([CH3:4])[CH3:3].[H][H]>[C].[Pd].O1CCCC1>[CH2:1]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[O:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)=[CH:9][C:8]=1[NH2:22])[C:2]([CH3:5])([CH3:4])[CH3:3]

참가 물질

5

반응물 2

HCID 674990142-(4-Neopentylamino-3-nitrophenyl)benzoxazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 674978662-(2-Neopentylaminoanilin-5-yl)benzoxazole수율 89.2%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a tetrahydrofuran solution (5 mL) of 2-(4-neopentylamino-3-nitrophenyl)benzoxazole (see Working Example 81-1) (242 mg, 0.744 mmol) was added 10% palladium-carbon (40 mg), a hydrogen atmosphere was substituted in the flask, and this was stirred at room temperature for 15 hours. After the reaction was complete, this was filtered through Celite and the filtrate was concentrated. The residue obtained was purified by silica gel column chromatography to yield the title compound (196 mg, 89% yield).

후처리

  1. filtrationthis was filtered through Celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue obtained
  4. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-11f03d1e0fb8423a8aaa20d19de03e28
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829035B2

연결된 노트

불러오는 중…