Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Ethanimidic acid, methyl ester, hydrochloride (1:1) | HCID 10313100 | — |
| 반응물 | 3-Amino-4-(propylamino)benzoic acid | HCID 11586440 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-Methyl-1-propyl-1,3-benzodiazole-5-carboxylic acid | HCID 20298856 | 116.5% |
반응 단계
To a methanol (17 mL) solution of 3-amino-4-n-propylaminobenzoic acid (see Working Example 82-2) (1.68 g, 8.65 mmol) was added methyl acetimidate hydrochloride (1.14 g, 10.4 mmol), and this was heated to reflux for 4 hours. After the reaction was complete, this was cooled to room temperature, diethyl ether was added, and this was allowed to stand at room temperature for 10 minutes. The crystals obtained were filtered, and after being washed with diethyl ether, they were dried to yield the title compound (2.20 g, quant.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829035B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3eb052daec9a47e6839ab79527356e8e |
| 출처 메모 | uspto-grants-2014_09 |