Triethylamine → N-methoxyacetyl-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamin

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	Methoxyacetic Acid	HCID 12251	—
반응물	Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate	HCID 151348	—
반응물	2-(3-(3,4-Dichlorophenyl)-4-aminobutyl)oxytetrahydropyran	HCID 15670808	—
용매	Dichloromethane	HCID 6344	—
생성물	N-methoxyacetyl-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamin	HCID 19705334	71.1%

반응 조건

온도	0 °C

반응 단계

A mixture of 8.6 g of 2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamine (obtained according to PREPARATION (I), step (b)), 2.46 g of methoxyacetic acid, 5.55 g of triethylamine in 50 ml of dichloromethane is cooled to 0° C. and 14.5 g of BOP is added thereto. The reaction mixture is stirred for one hour at room temperature and concentrated under vacuum. The residue is taken up in ethyl acetate and is successively washed with water, dried over Na2SO4 and concentrated under vacuum. The residue is chromatographed on silica gel using CH2Cl2/CH3OH (100/1 v/v) as the eluent to give 7.5 g of the expected product.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05554763
출처 데이터셋	uspto-grants-1996_09
ORD ID	ord-0c8ce3533d57469fb98ac376e471eabf
출처 메모	uspto-grants-1996_09