Tetrahydrofuran → 2-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazole

HRID 74279노트

반응식

HRID 74279 반응식
N1(C(C)C[NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[O:17][C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[N:20]=3)=[CH:12][C:11]=2[N+:25]([O-])=O)CCOCC1.[H][H].[O:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1>[C].[Pd]>[N:9]1([CH2:10][CH2:11][CH2:12][NH:25][C:11]2[CH:12]=[C:13]([C:16]3[O:17][C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[N:20]=3)[CH:14]=[CH:15][C:10]=2[NH2:9])[CH2:34][CH2:35][O:31][CH2:32][CH2:33]1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 674985632-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 674982532-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazole수율 99%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

To a solution of 2-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazole (see Working Example 96-1) (665 mg, 1.74 mmol) in tetrahydrofuran (10 mL) was added 10% palladium-carbon (70 mg). A hydrogen atmosphere was then substituted in the flask, and this was stirred at room temperature for 17 hours. After the reaction was finished, this was filtered through Celite, and the filtrate was concentrated to yield the title compound (605 mg, 99% yield).

후처리

  1. filtrationthis was filtered through Celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-29eb486814c94c0e888b39ee379cfbf7
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829035B2

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