2-(4-Chloro-2-(tetrahydropyran-4-yl)aminonitrobenzen-5-yl)benzoxazole → HCID 67498666, 화합물

HRID 74295노트

반응식

HRID 74295 반응식
[Cl:1][C:2]1[C:7]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:5]([N+:17]([O-])=O)=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[CH:3]=1>[Fe].C(O)(=O)C>[Cl:1][C:2]1[C:7]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][C:5]([NH2:17])=[C:4]([NH:20][CH:21]2[CH2:26][CH2:25][O:24][CH2:23][CH2:22]2)[CH:3]=1

참가 물질

4

반응물 1

HCID 674991902-(4-Chloro-2-(tetrahydropyran-4-yl)aminonitrobenzen-5-yl)benzoxazole

생성물 1

HCID 67498666HCID 67498666, 화합물수율 65%

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

To 2-(4-chloro-2-(tetrahydropyran-4-yl)aminonitrobenzen-5-yl)benzoxazole (see Working Example 112-2) (0.10 g, 0.8 mmol) was added iron powder (0.33 g, 5.8 mmol) and acetic acid (50 mL), and this was heated to reflux for 2 hours. After the reaction solution cooled, this was filtered through Celite and concentrated, and the residue obtained was purified by silica gel column chromatography to yield the title compound (0.06 g, 65% yield) as a reddish-brown solid.

후처리

  1. temperaturethis was heated
  2. temperatureto reflux for 2 hours
  3. temperatureAfter the reaction solution cooled
  4. filtrationthis was filtered through Celite
  5. concentrationconcentrated
  6. customthe residue obtained
  7. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-51ba33be36ca41aba9b8486e6733c2a6
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829035B2

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