Sodium Iodide → N-butyl-5-iodo-N-methyl-pentanesulfonamide
반응식
[I-:1].[Na+].[CH2:3]([N:7]([CH3:17])[S:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]Cl)(=[O:10])=[O:9])[CH2:4][CH2:5][CH3:6]>C(C(C)=O)C>[CH2:3]([N:7]([CH3:17])[S:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][I:1])(=[O:10])=[O:9])[CH2:4][CH2:5][CH3:6]참가 물질
4
실험 절차
526 mg of sodium iodide were added to a solution of 449 mg of the product of Step A in 4.5 ml of methyl ethyl ketone, and the mixture was stirred at reflux for 4 hours. After cooling, the methyl ethyl ketone was evaporated under reduced pressure and water was added. Extraction was carried out with ethyl acetate and the extracts were washed with water, then with a saturated aqueous solution of sodium chloride, dried and evaporated to dryness under reduced pressure to obtain 572 mg of the expected product.
후처리
- temperatureat reflux for 4 hours
- temperatureAfter cooling
- customthe methyl ethyl ketone was evaporated under reduced pressure and water
- additionwas added
- extractionExtraction
- washthe extracts were washed with water
- dry with materialwith a saturated aqueous solution of sodium chloride, dried
- customevaporated to dryness under reduced pressure
출처 및 근거
- ORD 기록
- ord-23d789ad91c24812bc180d0a32b101da
- 출처 데이터셋
- uspto-grants-1996_09
- 특허 번호
- US05556845
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