Epibromohydrin → 2-{2-[4-(2-Methoxyphenyl)butyl]phenoxymethyl}oxirane

HRID 743196노트

반응식

HRID 743196 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19].[CH3:20][C:21](C)([O-:23])[CH3:22].[K+].C(C1OC1)Br>CC(N(C)C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH2:20][CH:21]1[CH2:22][O:23]1

참가 물질

5

반응물 3

HCID 18430EpibromohydrinHCID 194239792-[4-(2-Methoxyphenyl)butyl]phenolHCID 23665647Potassium tert-butoxide

생성물 1

HCID 106388632-{2-[4-(2-Methoxyphenyl)butyl]phenoxymethyl}oxirane수율 93%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

Following a procedure similar to that described in Example 1(a), 230 mg of 2-[4-(2-methoxyphenyl)butyl]phenol (prepared as described in Preparation 4), 101 mg of potassium t-butoxide and 246 mg of epibromohydrin were reacted in 15 ml of dimethylacetamide. The crude product, extracted as described in Example 1(a), was purified as described in Example 1(a), to give 260 mg (yield 93%) of the title compound as an oil.

후처리

  1. extractionThe crude product, extracted
  2. customwas purified

출처 및 근거

ORD 기록
ord-26eb422a15f1495bbb522969fe987898
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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