Imidazole → 3-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol

HRID 743206노트

반응식

HRID 743206 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[C:6]1([CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[CH:26]=[CH:25][CH:24]=[CH:23][C:17]=2[O:18][CH2:19][CH:20]2[CH2:22][O:21]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C(#N)C>[N:1]1([CH2:22][CH:20]([OH:21])[CH2:19][O:18][C:17]2[CH:23]=[CH:24][CH:25]=[CH:26][C:16]=2[CH2:15][CH2:14][CH2:13][CH2:12][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 104931782-[2-(4-Phenylbutyl)phenoxymethyl]oxirane

생성물 1

HCID 194239523-(Imidazol-1-yl)-1-[2-(4-phenylbutyl)phenoxy]-2-propanol수율 82.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

940 mg of imidazole were added to a solution of 780 mg of 2-[2-(4-phenylbutyl)phenoxymethyl]oxirane [prepared as described in Example 1(a)] in 25 ml of acetonitrile, and the resulting mixture was heated under reflux for 24 hours. At the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 20:1 by volume mixture of methylene chloride and methanol as the eluent, to give 798 mg (yield 82%) of the title compound as a pale yellow oil.

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 24 hours
  3. distillationAt the end of this time, the reaction mixture was freed from the solvent by distillation under reduced pressure
  4. customThe resulting residue was purified by column chromatography through silica gel
  5. additionby volume mixture of methylene chloride and methanol as the eluent

출처 및 근거

ORD 기록
ord-8f9b8976c0804d67855e7f0e00a7aedc
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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