Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1) → 2-(2-{2-[2-(3-Methoxymethoxyphenyl)ethyl]phenoxy}ethyl]-1-methylpyrrolidin

HRID 743252노트

반응식

HRID 743252 반응식
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[OH:19])[CH:8]=[CH:9][CH:10]=1.CC(C)([O-])C.[K+].Cl.Cl[CH2:28][CH2:29][CH:30]1[CH2:34][CH2:33][CH2:32][N:31]1[CH3:35]>CC(N(C)C)=O>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[O:19][CH2:28][CH2:29][CH:30]2[CH2:34][CH2:33][CH2:32][N:31]2[CH3:35])[CH:8]=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 3017050Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1)HCID 194238312-[2-(3-Methoxymethoxyphenyl)ethyl]phenolHCID 23665647Potassium tert-butoxide

생성물 1

HCID 194238962-(2-{2-[2-(3-Methoxymethoxyphenyl)ethyl]phenoxy}ethyl]-1-methylpyrrolidin수율 62%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

Following a procedure similar to that described in Example 35(a), 2.37 g of 2-[2-(3-methoxymethoxyphenyl)ethyl]phenol (prepared as described in Preparation 21), 1.03 g of potassium t-butoxide and 1.69 g of 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride were reacted in 50 ml of dimethylacetamide. The reaction mixture was then worked up as described in Example 35(a), and the crude product was purified by column chromatography through silica gel, using a 20:1 by volume mixture of methylene chloride and methanol as the eluent, to give 1.87 g (yield 62%) of the title compound as a colorless oil.

후처리

  1. customthe crude product was purified by column chromatography through silica gel
  2. additionby volume mixture of methylene chloride and methanol as the eluent

출처 및 근거

ORD 기록
ord-e57a6f532cd94ad2914919b13c27bbda
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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