1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-(2-Benzyloxyphenyl)-4-(3-methoxymethoxyphenyl)butadiene

HRID 743389

반응식

HRID 743389 반응식
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=O)[CH:8]=[CH:9][CH:10]=1.[Cl-].[CH2:16]([O:23][C:24]1[CH:49]=[CH:48][CH:47]=[CH:46][C:25]=1[CH2:26][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N12CCCN=C1CCCCC2>C(#N)C>[CH2:16]([O:23][C:24]1[CH:49]=[CH:48][CH:47]=[CH:46][C:25]=1[CH:26]=[CH:13][CH:12]=[CH:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH2:3][O:2][CH3:1])[CH:6]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 194239672-Benzyloxybenzyltriphenylphosphonium chlorideHCID 544620843-(3-Methoxymethoxyphenyl)-2-propenal

생성물 1

HCID 544364151-(2-Benzyloxyphenyl)-4-(3-methoxymethoxyphenyl)butadiene수율 88.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following a procedure similar to that described in the first part of Preparation 3, 7.00 g of 3-(3-methoxymethoxyphenyl)-2-propenal and 18 g of 2-benzyloxybenzyltriphenylphosphonium chloride (prepared as described in Preparation 1) were dissolved in 200 ml of acetonitrile, with heating, and 5.54 g of 1,8-diazabicyclo[5,4,0]undec-7-ene were added to the mixture and reacted. The crude product, extracted as described in Preparation 3, was purified as described in Preparation 3, to give 12.0 g of 1-(2-benzyloxyphenyl)-4-(3-methoxymethoxyphenyl)butadiene as a colorless oil.

후처리

  1. temperaturewith heating
  2. customreacted
  3. extractionThe crude product, extracted
  4. customas described in Preparation 3
  5. customwas purified
  6. customas described in Preparation 3

출처 및 근거

ORD 기록
ord-774c2abdd8714b82b1761ba509dca917
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

연결된 노트

불러오는 중…