1,8-Diazabicyclo(5.4.0)undec-7-ene → 1-(2-Benzyloxyphenyl)-4-(3-chlorophenyl)butadiene

HRID 743399

반응식

HRID 743399 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=O)[CH:5]=[CH:6][CH:7]=1.[Cl-].[CH2:13]([O:20][C:21]1[CH:46]=[CH:45][CH:44]=[CH:43][C:22]=1[CH2:23][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.N12CCCN=C1CCCCC2>C(#N)C>[CH2:13]([O:20][C:21]1[CH:46]=[CH:45][CH:44]=[CH:43][C:22]=1[CH:23]=[CH:10][CH:9]=[CH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 27631113-(3-Chlorophenyl)prop-2-enalHCID 194239672-Benzyloxybenzyltriphenylphosphonium chloride

생성물 1

HCID 545226781-(2-Benzyloxyphenyl)-4-(3-chlorophenyl)butadiene수율 94%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following a procedure similar to that described in the first part of Preparation 3, the whole of this 3-(3-chlorophenyl)-2-propenal was reacted with 6.9 g of 2-benzyloxybenzyltriphenylphosphonium chloride (prepared as described in Preparation 1) and 2.89 g of 1,8-diazabicyclo[5,4,0]undec-7-ene in 100 ml of acetonitrile. The crude product, extracted as described in the first part of Preparation 3, was purified as described in the first part of Preparation 3, to give 4.13 g (yield 94%) of 1-(2-benzyloxyphenyl)-4-(3-chlorophenyl)butadiene as an oil.

후처리

  1. customthat described in the first part of Preparation 3
  2. extractionThe crude product, extracted
  3. customas described in the first part of Preparation 3
  4. customwas purified
  5. customas described in the first part of Preparation 3

출처 및 근거

ORD 기록
ord-9d499ca1328845e99ea443d258b77e96
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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