2-Chlorobenzaldehyde → 2-Chlorocinnamaldehyde

HRID 743402

반응식

HRID 743402 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.C1(P(=[CH:29][CH:30]=[O:31])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(#N)C>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[CH:29][CH:30]=[O:31]

참가 물질

4

반응물 2

HCID 69962-ChlorobenzaldehydeHCID 75051(Triphenylphosphoranylidene)acetaldehyde

생성물 1

HCID 30140422-Chlorocinnamaldehyde수율 68.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following a procedure similar to that described in the first part of Preparation 17, 3.00 g of 2-chlorobenzaldehyde and 7.5 g of (triphenylphosphoranylidene)acetaldehyde were reacted in 100 ml of acetonitrile. The crude product thus obtained was purified by column chromatography through silica gel, using a 4:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 2.44 g (yield 68%) of 3-(2-chlorophenyl)-2-propenal as a solid.

후처리

  1. customThe crude product thus obtained
  2. customwas purified by column chromatography through silica gel
  3. additionby volume mixture of hexane and ethyl acetate as the eluent

출처 및 근거

ORD 기록
ord-3ec02909709d487c874bb027c60589aa
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556864

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