Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(Bromomethyl)cyclobutane → 2-(3-(3-(Cyclobutylmethoxy)phenyl)propyl)isoindoline-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (Bromomethyl)cyclobutane | HCID 2734658 | — |
| 반응물 | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| 생성물 | 2-(3-(3-(Cyclobutylmethoxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67316929 | — |
반응 단계
Alkylation reaction of phenol 58 with cyclobutylmethyl bromide gave 2-(3-(3-(cyclobutylmethoxy)phenyl)propyl)isoindoline-1,3-dione as yellow oil. Yield (0.430 g, 34%): 1H NMR (400 MHz, CDCl3) δ 7.82-7.84 (m, 2H), 7.69-7.71 (m, 2H), 7.11-7.16 (m, 1H), 6.73-6.78 (m, 2H), 6.66 (dd, J=7.6, 2.4 Hz, 1H), 3.88 (d, J=6.4 Hz, 2H), 3.75 (t, J=7.2 Hz, 2H), 2.70-2.79 (m, 1H), 2.66 (t, J=8.0 Hz, 2H), 2.10-2.17 (m, 2H), 2.00-2.07 (m, 2H), 1.82-1.98 (m, 4H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829244B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-82055c7ab4a742ccb040dcd005d52371 |
| 출처 메모 | uspto-grants-2014_09 |