Methylamine → 1-(Diphenylmethyl)-N-methylazetidin-3-amine

HRID 743663노트

반응식

HRID 743663 반응식
[CH:1]([N:14]1[CH2:17][CH:16](OS(C)(=O)=O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][NH2:24]>CO>[CH:1]([N:14]1[CH2:17][CH:16]([NH:24][CH3:23])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 27587161-(Diphenylmethyl)azetidin-3-yl methanesulfonate

생성물 1

HCID 503191-(Diphenylmethyl)-N-methylazetidin-3-amine수율 67.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1-Benzhydryl-3-(methylamino)azetidine was prepared under the conditions of Example 9, but starting with 50 g of 1-benzhydryl-3-(methanesulphonyloxy)-azetidine and 48.9 g of methylamine in 250 cm3 of methanol. 27 g of 1-benzhydryl-3-(methylamino)azetidine are obtained in the form of a colorless solid, melting point 75° C.

후처리

  1. custom1-Benzhydryl-3-(methylamino)azetidine was prepared under the conditions of Example 9

출처 및 근거

ORD 기록
ord-a5d9d18420604078a9804d62c30246f3
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556861

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