4-Benzyloxy [4-(4-pyridyl)piperazin-2-one-1-yl]benzene → 4-[4-(4-Pyridyl)piperazin-2-one-1-yl]phenol

HRID 743852

반응식

HRID 743852 반응식
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)[CH2:17][C:16]2=[O:27])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>CO.O1CCCC1.[Pd]>[N:24]1[CH:25]=[CH:26][C:21]([N:18]2[CH2:19][CH2:20][N:15]([C:12]3[CH:11]=[CH:10][C:9]([OH:8])=[CH:14][CH:13]=3)[C:16](=[O:27])[CH2:17]2)=[CH:22][CH:23]=1

참가 물질

6

반응물 2

HCID 542272954-Benzyloxy [4-(4-pyridyl)piperazin-2-one-1-yl]benzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 189184154-[4-(4-Pyridyl)piperazin-2-one-1-yl]phenol

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the product of step (i) (1.1 g) in a mixture of methanol (500 ml) and tetrahydrofuran (100 ml) was added 30% palladium-on-charcoal catalyst (300 mg) and the mixture stirred in an atmosphere of hydrogen at ambient temperature and pressure until all the starting material had been consumed. After removal of the catalyst by filtration, the solvent was evaporated in vacuo to give 4-[4-(4-pyridyl)piperazin-2-one-1-yl]phenol as a colourless solid, essentially one spot by tlc, which was used without further purification or characterisation.

후처리

  1. custompressure until all the starting material had been consumed
  2. customAfter removal of the catalyst
  3. filtrationby filtration
  4. customthe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-1e2ddc42f7424b8fbe1cba4ab884d3a6
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556977

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