Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylbenzyl alcohol → 2-(3-(3-(4-Methylbenzyloxy)phenyl)propyl)isoindoline-1,3-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylbenzyl alcohol | HCID 11505 | — |
| 반응물 | 2-[3-(3-Hydroxyphenyl)propyl]isoindole-1,3-dione | HCID 58027542 | — |
| 생성물 | 2-(3-(3-(4-Methylbenzyloxy)phenyl)propyl)isoindoline-1,3-dione | HCID 67316047 | — |
반응 단계
Mitsunobu coupling of phenol 58 with 4-methylbenzylalcohol followed by flash chromatography (5 to 30% EtOAc-hexanes gradient) gave 2-(3-(3-(4-methylbenzyloxy)phenyl)propyl)isoindoline-1,3-dione as a white waxy solid. Yield (2.6 g, 69%): 1H NMR (400 MHz, CDCl3) δ 7.80 (dd, J=3.2 Hz, 2H), 7.67 (d, J=3.2 Hz, 2H), 7.32 (d, J=8.0 Hz, 2H), 7.16 (dd, J=8.0 Hz, 3H), 6.75-6.85 (m, 3H), 4.98 (s, 2H), 3.74 (t, J=8.0, 2H), 2.67 (t, J=8.0 Hz, 2H), 2.35 (s, 3H), 2.04 (dddd, J=8.0, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829244B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-463b2de60dff425b9c283c560ee5637d |
| 출처 메모 | uspto-grants-2014_09 |