Nitric Acid → 2-(3-Methyl-4-nitrophenyl)benzonitrile

HRID 743893

반응식

HRID 743893 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1.[N+:16]([O-])([OH:18])=[O:17].S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[N+:16]([O-:18])=[O:17]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 13942432-(3-Methylphenyl)benzonitrile

생성물 1

HCID 214689052-(3-Methyl-4-nitrophenyl)benzonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-(3-Methylphenyl)benzonitrile (18.1 mmoles, 3.5 g) was added slowly at -5° C. to a mixture of 10 ml nitric acid and 10 ml sulfuric acid. After 5 minutes, the reaction was diluted with cold water. The solid was collected, dissolved in THF. The solution was dried and concentrated. The solid was recrystallized from ether and hexane to yield 2.45 g of 2-(3-methyl-4-nitrophenyl)benzonitrile. (MS)

후처리

  1. customThe solid was collected
  2. dissolutiondissolved in THF
  3. customThe solution was dried
  4. concentrationconcentrated
  5. customThe solid was recrystallized from ether and hexane

출처 및 근거

ORD 기록
ord-dbd7b52f29554acc8a2fd831e90ff280
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05556981

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