4,6-Dimethoxy-2-(2-nitrobenzyl)pyrimidine → 2-(4,6-Dimethoxypyrimidin-2-ylmethyl)aniline
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[N:4]=1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[N:4]=1참가 물질
3
실험 절차
The product of stage (i) (32.6 g) was added to a stirred suspension of stannous chloride dihydrate (133 g) in ethanol (300 ml). After refluxing for 2 hours, the solution was poured into ice-water (2500 ml) and extracted with ethyl acetate (3×500 ml). The combined extracts were washed with saturated sodium chloride solution, dried and evaporated to give 24.3 g of the desired product as a brown solid, mp 82°-84° C.
후처리
- temperatureAfter refluxing for 2 hours
- extractionextracted with ethyl acetate (3×500 ml)
- washThe combined extracts were washed with saturated sodium chloride solution
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-adf3e20eb4b147c39b65c2b8932dc558
- 출처 데이터셋
- uspto-grants-1996_09
- 특허 번호
- US05559081
반응 노트
불러오는 중…