3-Phenylpropylamine → N-(3-Phenylpropyl)-3-(1H-imidazol-4-yl)propanamide

반응식

[C:1]1([CH2:7][CH2:8][CH2:9][NH2:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:11]1[CH:15]=[C:14]([CH2:16][CH2:17][C:18](O)=[O:19])[N:13]=[CH:12]1>>[C:1]1([CH2:7][CH2:8][CH2:9][NH:10][C:18](=[O:19])[CH2:17][CH2:16][C:14]2[N:13]=[CH:12][NH:11][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 162593-Phenylpropylamine

HCID 178525356HCID 178525356, 화합물

생성물 1

HCID 178520519N-(3-Phenylpropyl)-3-(1H-imidazol-4-yl)propanamide

실험 절차

The preparation is carried out as in Example 1 with 3-phenylpropanamine and 3-(1H-imidazol-4-yl)propanoic acid, the acid being here added after the reaction of the amine component with N,N'-carbonyldiimidazole. The title compound is extracted from water with diethyl ether, purified by chromatography and recrystallized in the hydrogenmaleate form from ethanol/diethyl ether.

후처리

additionthe acid being here added
extractionThe title compound is extracted from water with diethyl ether
custompurified by chromatography
customrecrystallized in the hydrogenmaleate form from ethanol/diethyl ether

출처 및 근거

ORD 기록: ord-424f81e7bb5f47f0b2ca280258f28261
출처 데이터셋: uspto-grants-1996_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05559113

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