HCID 57432834, 화합물 → (2S,3S,4R,5S)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

HRID 744166노트

반응식

HRID 744166 반응식
C([O:9][C@H:10]1[C@@H:14]([O:15]C(=O)C2C=CC=CC=2)[C@H:13]([CH2:24][O:25]C(=O)C2C=CC=CC=2)[O:12][C@@H:11]1[N:34]1[CH:42]=[N:41][C:40]2[C:35]1=[N:36][CH:37]=[N:38][C:39]=2Cl)(=O)C1C=CC=CC=1.COCCOC.[NH3:50]>N.CO>[C@H:11]1([N:34]2[CH:42]=[N:41][C:40]3[C:35]2=[N:36][CH:37]=[N:38][C:39]=3[NH2:50])[O:12][C@@H:13]([CH2:24][OH:25])[C@H:14]([OH:15])[C@@H:10]1[OH:9]

참가 물질

4

반응물 2

HCID 57432834HCID 57432834, 화합물HCID 86749850[(2S,3S,4S,5S)-3,4-dibenzoyloxy-5-(6-chloropurin-9-yl)oxolan-2-yl]methyl benzoate

생성물 1

HCID 448374(2S,3S,4R,5S)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol수율 67%

시약·촉매·용매 1

HCID 21705897Ammonia methanol용매

실험 절차

A solution of 9 (1.00 g) in DME/NH3 (50 ml) was heated at 80° C. in a steel bomb for 24 hours. After cooling, the solvent was evaporated and the solid obtained was stirred in NH3 /MeOH (100 ml) overnight. After the evaporation of the solvent, the residue was dissolved in water (50 ml), washed with CHCl3 (2×25 ml) and ether (2×25 ml). The water layer was evaporated and the residue crystallized from water to give pure 10 (0.30 g, 67%) as white crystals: m.p. 225° C. (dec).

후처리

  1. temperatureAfter cooling
  2. customthe solvent was evaporated
  3. customthe solid obtained
  4. customAfter the evaporation of the solvent
  5. dissolutionthe residue was dissolved in water (50 ml)
  6. washwashed with CHCl3 (2×25 ml) and ether (2×25 ml)
  7. customThe water layer was evaporated
  8. customthe residue crystallized from water

출처 및 근거

ORD 기록
ord-e2a5092893a747d8a148475980ac4abc
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559101

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