Methylamine → 3-Benzyloxycarbonylamino-2(R,S)-methylpropionic acid N-methylamide

HRID 744847노트

반응식

HRID 744847 반응식
C[O:2][C:3](=O)[CH:4]([CH3:17])[CH2:5][NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8].[CH3:19][NH2:20]>>[CH3:19][NH:20][C:3](=[O:2])[CH:4]([CH3:17])[CH2:5][NH:6][C:7]([O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:8]

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 223644703-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester

생성물 1

HCID 223644733-Benzyloxycarbonylamino-2(R,S)-methylpropionic acid N-methylamide

실험 절차

2.52 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid methyl ester and 50 ml of 33% methylamine (in ethanol) are stirred at room temperature for 48 hours. The reaction mixture is concentrated by evaporation and the title compound is obtained from the residue by crystallisation from ethyl acetate: Rf (dichloromethane/methanol=95:5)=0.42; m.p. 128°-129° C.

후처리

  1. concentrationThe reaction mixture is concentrated by evaporation

출처 및 근거

ORD 기록
ord-c54887840c3b4e3dbf1613b530028b60
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05559111

반응 노트

불러오는 중…