Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid | HCID 304274 | — |
| 촉매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester | HCID 22364470 | — |
반응 단계
22.6 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid are left to stand for 24 hours in 230 ml of methanol with a few drops of concentrated sulfuric acid. The reaction mixture is concentrated by evaporation and the residue is purified by FC (220 g of silica gel, dichloromethane). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.60.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05559111 |
| 출처 데이터셋 | uspto-grants-1996_09 |
| ORD ID | ord-cc8983031c1e457db04f9006e1139e60 |
| 출처 메모 | uspto-grants-1996_09 |