Aluminium lithium hydride → Indole, 3-(1-methyl-2-piperidylmethyl)-

To a stirred solution of (R)- or (S)-(N-benzyloxycarbonylpyrrolidin-2-ylcarbonyl)-1H-indole, (R)-, (S), or (R,S)-(N-benzyloxycarbonylazetidin-2-ylcarbonyl)-1H-indole, or (R)-, (S)-, or (R,S)-(N-benzyloxycarbonylpiperidin-2-ylcarbonyl)-1H-indole, (5.00 mmol) in anhydrous tetrahydrofuran (20 mL) at room temperature under nitrogen was carefully added lithium aluminum hydride (0.57 g, 15.0 mmol, 3.0 eq) as a powder, and the resulting mixture was stirred at room temperature under nitrogen for 1 hour. The mixture was then heated at reflux (66° C.) under nitrogen for 12 hours. The reaction was then quenched with successive additions of water (0.5 mL), aqueous sodium hydroxide (20%, 0.5 mL), and then additional water (1.0 mL), and the resulting mixture filtered through diatomaceous earth (Celite (trademark)). The solids were then washed with copious amounts of ethyl acetate (50 mL). The combined filtrate was then washed with water (20 mL), dried (MgSO4), and evaporated under reduced pressure. The residue was then column chromatographed using silica gel (50 g) and elution with the appropriate solvent system to afford the 3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 3-(N-methylazetidin-2-ylmethyl)-1H-indole, or 3-(N-methylpiperidin-2-ylmethyl)-1H-indole. Following this procedure the following compounds were prepared:

1. customat room temperature
2. temperatureThe mixture was then heated
3. temperatureat reflux (66° C.) under nitrogen for 12 hours
4. customThe reaction was then quenched with successive additions of water (0.5 mL), aqueous sodium hydroxide (20%, 0.5 mL)
5. filtrationadditional water (1.0 mL), and the resulting mixture filtered through diatomaceous earth (Celite (trademark))
6. washThe solids were then washed with copious amounts of ethyl acetate (50 mL)
7. washThe combined filtrate was then washed with water (20 mL)
8. dry with materialdried (MgSO4)
9. customevaporated under reduced pressure
10. customcolumn chromatographed
11. washsilica gel (50 g) and elution with the appropriate solvent system

ORD 기록

ord-826636ad67964faea03a6ea1fbe663b9

출처 데이터셋

uspto-grants-1996_09

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05559246