Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indoline → (2-Chloropyridin-4-yl)-(2,3-dihydroindol-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indoline | HCID 10328 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Chloroisonicotinic acid | HCID 236985 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (2-Chloropyridin-4-yl)-(2,3-dihydroindol-1-yl)-methanone | HCID 28376039 | — |
반응 단계
400 μL (3.53 mmol) 2,3-dihydro-1H-indole were added to 500 mg (3.17 mmol) 2-chloroisonicotinic acid, 600 μL (3.49 mmol) DIPEA and 1.10 g (3.43 mmol) TBTU in 20 mL THF. The reaction mixture was stirred overnight, diluted with ethyl acetate and washed with 15% potassium carbonate solution (1×), water (1×) and 1M hydrochloric acid (1×). The organic phase was dried on magnesium sulphate, filtered and evaporated down i. vac. The residue was triturated with diisopropylether and suction filtered. The solid was dried at 40° C. in the circulating air dryer.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-f7906a4de1474d21a55b05796cf0e145 |
| 출처 메모 | uspto-grants-2014_09 |