Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Chloroisonicotinic acid | HCID 236985 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 반응물 | 5-Fluoroindoline | HCID 2774463 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (2-Chloropyridin-4-yl)-(5-fluoro-2,3-dihydroindol-1-yl)-methanone | HCID 58386590 | — |
반응 단계
174 mg (1.27 mmol) 5-fluoro-2,3-dihydro-1H-indole were added to 198 mg (1.26 mmol) 2-chloroisonicotinic acid, 351 μL (2.50 mmol) triethylamine and 434 mg (1.35 mmol) TBTU in 3 mL DMF. The reaction mixture was stirred overnight at RT. Purification was carried out by preparative HPLC. The product fractions were combined and evaporated down i. vac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-5d720ad4a5af4249b03846e9b4bcd2f1 |
| 출처 메모 | uspto-grants-2014_09 |