Maleic Acid → T-817 maleate

HRID 7451

반응식

HRID 7451 반응식
[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[C:21]([OH:28])(=[O:27])/[CH:22]=[CH:23]\[C:24]([OH:26])=[O:25]>CC(C)=O>[C:21]([OH:28])(=[O:27])/[CH:22]=[CH:23]\[C:24]([OH:26])=[O:25].[S:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][O:12][CH2:13][CH2:14][CH2:15][N:16]3[CH2:19][CH:18]([OH:20])[CH2:17]3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 444266Maleic AcidHCID 9901946Edonerpic

생성물 1

HCID 11338749T-817 maleate수율 88.4%

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
5 °C

실험 절차

In 56 mL of acetone was dissolved 8.00 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol, followed by adding thereto 3.19 g of maleic acid, and the resulting mixture was heated at 60° C. to effect dissolution. The reaction mixture was slowly cooled and then stirred at 5° C. for 30 minutes. The crystals precipitated were collected by filtration to obtain 9.89 g of 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl}-3-azetidinol maleate as colorless crystals.

후처리

  1. additionby adding
  2. dissolutiondissolution
  3. temperatureThe reaction mixture was slowly cooled
  4. customThe crystals precipitated
  5. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-dbe896ef33d741a789d2585a245fe8e0
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087594B2

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