Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Octahydro-1H-indole | HCID 107275 | — |
| 반응물 | 6-Chloropyrimidine-4-carbonyl chloride | HCID 18422098 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (6-Chloropyrimidin-4-yl)-(octahydroindol-1-yl)-methanone | HCID 58386728 | — |
반응 단계
0.517 g (2.92 mmol) 6-chloropyrimidine-4-carboxylic acid chloride in 10 mL dichloromethane were combined with 1.07 mL (6.00 mmol) DIPEA. 0.73 g (2.92 mmol) octahydroindole in 10 mL DCM was slowly added dropwise. After 2 h stirring at RT the mixture was diluted with dichloromethane and extracted with water. The organic phase was separated off, dried on sodium sulphate, filtered, evaporated down i. vac. and dried.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d9e6d1a79cb5434b9b413788f1e27a35 |
| 출처 메모 | uspto-grants-2014_09 |