Methylamine → ([2-(Methylamino)ethyl]sulfonyl)benzene

HRID 745169

반응식

HRID 745169 반응식
Cl[CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5].[CH3:13][NH2:14]>C(#N)C>[CH3:13][NH:14][CH2:2][CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 13646((2-Chloroethyl)sulphonyl)benzene

생성물 1

HCID 5152138([2-(Methylamino)ethyl]sulfonyl)benzene

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

후처리

  1. customThe solvent is removed in vacuo
  2. customthe residue is partitioned between methylene chloride and dilute sodium hydroxide
  3. extractionThe methylene chloride solution is extracted with dilute sulfuric acid
  4. extractionThe acidic extract
  5. extractionthe basic solution is extracted with methylene chloride
  6. dry with materialThe methylene chloride solution is dried over magnesium sulfate
  7. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-4bcb9985990d4f0a9ba58e9444d206e9
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04597902

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