Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenethylamine → N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenethylamine | HCID 1001 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | ((2-Chloroethyl)sulphonyl)benzene | HCID 13646 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate | HCID 131714769 | 89.1% |
반응 단계
A mixture of 70.23 g (0.344 mole) of 2-chloroethylphenylsulfone, 41.92 g (0.343 mole) of phenethylamine and 60 ml of triethylamine in 800 ml of acetonitrile was stirred at room temperature for 18 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol and excess to ethereal hydrogen chloride was added and ether was added. A white solid precipitated to give 68.39 g (60%) of white crystalline solid, m.p. 194°-196° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04597902 |
| 출처 데이터셋 | uspto-grants-1986_07 |
| ORD ID | ord-ee976a2410fd422094e3c1c5f08f6515 |
| 출처 메모 | uspto-grants-1986_07 |