N,N-Diethylethylenediamine → N'-[2-(Diethylamino)ethyl]-N-(1-methylethyl)-N-[1-methyl-2-(phenylsulfonyl)ethyl]urea hydrate

HRID 745195

반응식

HRID 745195 반응식
[CH2:1]([N:3]([CH2:7][CH3:8])[CH2:4][CH2:5][NH2:6])[CH3:2].[C:9](N1C=CN=C1)(N1C=CN=C1)=[O:10].[CH3:21][CH:22]([NH:24][CH:25]([CH3:36])[CH2:26][S:27]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)(=[O:29])=[O:28])[CH3:23]>O1CCCC1>[OH2:10].[CH2:1]([N:3]([CH2:7][CH3:8])[CH2:4][CH2:5][NH:6][C:9](=[O:10])[N:24]([CH:22]([CH3:21])[CH3:23])[CH:25]([CH3:36])[CH2:26][S:27]([C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)(=[O:28])=[O:29])[CH3:2]

참가 물질

5

반응물 3

HCID 60993N,N-DiethylethylenediamineHCID 682631,1'-CarbonyldiimidazoleHCID 13655091N-(2-propyl)-1-(phenylsulfonyl)-2-propanamine

생성물 1

HCID 13655155N'-[2-(Diethylamino)ethyl]-N-(1-methylethyl)-N-[1-methyl-2-(phenylsulfonyl)ethyl]urea hydrate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 3.71 g (0.032 mole) of N,N-diethylethylenediamine and 5.83 (0.036 mole) of 1,1'-carbonyldiimidazole in 400 ml of tetrahydrofuran was stirred at room temperature for 1 hr. A solution of 8.30 g (0.030 mole) of N-(2-propyl)-1-(phenylsulfonyl)-2-propanamine in 50 ml of tetrahydrofuran was added and the solution was refluxed overnight. The solvent was removed in vacuo, and the residue was partitioned between ether and water. The ether solution was dried over magnesium sulfate and the solvent was removed in vacuo to give an oil. The oil was flash chromatographed (silica gel; elution with methanol) to give an oil. Crystallization from ether gave 0.54 g (4.5%) of white, crystalline solid, m.p. 75°-80° C.

후처리

  1. temperaturethe solution was refluxed overnight
  2. customThe solvent was removed in vacuo
  3. customthe residue was partitioned between ether and water
  4. dry with materialThe ether solution was dried over magnesium sulfate
  5. customthe solvent was removed in vacuo
  6. customto give an oil
  7. customchromatographed
  8. wash(silica gel; elution with methanol)
  9. customto give an oil
  10. customCrystallization from ether
  11. customgave 0.54 g (4.5%) of white, crystalline solid, m.p. 75°-80° C.

출처 및 근거

ORD 기록
ord-f16b105db12b494fba7b6c0c4a34a623
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04597902

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