Water → HCID 58386508, 화합물

HRID 74522

반응식

HRID 74522 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[NH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][CH2:17][C:18]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=O)=[CH:8]1.O>C1COCC1>[N:20]1([CH2:18][CH2:17][CH2:16][C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:7][CH:8]=2)[CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

5

반응물 3

HCID 962WaterHCID 48067833-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-oneHCID 21226445Aluminium lithium hydride

생성물 1

HCID 58386508HCID 58386508, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Under a nitrogen atmosphere 3.40 mL (3.40 mmol) of a 1M lithium aluminium hydride solution in THF was slowly added dropwise to 670 mg (2.77 mmol) 3-(1H-indol-3-yl)-1-pyrrolidin-1-yl-propan-1-one in 30 mL THF. The reaction mixture was stirred for 1 h at 65 C and after cooling combined with 1 mL water. After 10 min stirring at RT the organic phase was dried on sodium sulphate and evaporated down i. vac. The product was reacted further without any further purification.

후처리

  1. temperatureafter cooling
  2. stirringAfter 10 min stirring at RT the organic phase
  3. customwas dried on sodium sulphate
  4. customevaporated down i
  5. customThe product was reacted further without any further purification

출처 및 근거

ORD 기록
ord-39f6eb522e4e4be3be7652d682775701
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

연결된 노트

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