Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1-Methylpiperazine | HCID 53167 | — |
| 반응물 | 1-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene | HCID 13251817 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine | HCID 13251981 | 93.6% |
반응 단계
533 g of 3-(4-tert.butylphenyl)-2-methylpropyl chloride and 714 g of 4-methylpiperazine were stirred for 7 hours at 140° C. and then cooled to +10° C. in an ice bath, and 400 ml of 50% strength sodium hyroxide solution were added slowly, followed by the addition of 500 ml of ether. The organic phase was separated off, dried over sodium hydroxide and distilled to give 640 g of 1-methyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazine of boiling point 135°-140° C./0.3 mbar.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04599335 |
| 출처 데이터셋 | uspto-grants-1986_07 |
| ORD ID | ord-8bdee9547f6c4f59aa42d2195697c970 |
| 출처 메모 | uspto-grants-1986_07 |