2-Chloroisonicotinic acid → (2-Chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

HRID 74549

반응식

HRID 74549 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([OH:7])=O.Cl.[F:12][C:13]1[C:21]([F:22])=[CH:20][CH:19]=[C:18]2[C:14]=1[CH2:15][CH2:16][NH:17]2>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([N:17]2[C:18]3[C:14](=[C:13]([F:12])[C:21]([F:22])=[CH:20][CH:19]=3)[CH2:15][CH2:16]2)=[O:7])[CH:8]=[CH:9][N:10]=1

참가 물질

3

반응물 2

HCID 2369852-Chloroisonicotinic acidHCID 447549184,5-Difluoroindoline hydrochloride

생성물 1

HCID 58117528(2-Chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

실험 절차

Analogously to (4-chloro-pyridin-2-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone this compound was prepared from 500 mg (3.17 mmol) 2-chloroisonicotinic acid and 1.0 eq 4,5-difluoroindoline hydrochloride.

출처 및 근거

ORD 기록
ord-f74180017d5443d995723548e5b8ced9
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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