3-(2-Amino-2-methylpropylthio)-6-chloropyridazine → 1-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol

HRID 745504

반응식

HRID 745504 반응식
[NH2:1][C:2]([CH3:13])([CH3:12])[CH2:3][S:4][C:5]1[N:6]=[N:7][C:8]([Cl:11])=[CH:9][CH:10]=1.[CH3:14][O:15][CH2:16][CH2:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[O:20][CH2:21][CH:22]1[O:24][CH2:23]1>CO>[CH3:14][O:15][CH2:16][CH2:17][C:18]1[CH:28]=[CH:27][CH:26]=[CH:25][C:19]=1[O:20][CH2:21][CH:22]([OH:24])[CH2:23][NH:1][C:2]([CH3:13])([CH3:12])[CH2:3][S:4][C:5]1[N:6]=[N:7][C:8]([Cl:11])=[CH:9][CH:10]=1

참가 물질

4

반응물 2

HCID 104659523-(2-Amino-2-methylpropylthio)-6-chloropyridazineHCID 233133692-[[2-(2-Methoxyethyl)phenoxy]methyl]oxirane

생성물 1

HCID 539708411-[2-(2-Methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol수율 27.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 980 mg of 3-(2-amino-2-methylpropylthio)-6-chloropyridazine and 960 mg of 1-[2-(2-methoxyethyl)phenoxy]-2,3-epoxypropane in 60 ml of methanol was treated in the same way as in Example 1, (b) to give 534 mg of 1-[2-(2-methoxyethyl)phenoxy]-3-[1,1-dimethyl-2-(3-chloro-6-pyridazinylthio)ethylamino]-2-propanol.

출처 및 근거

ORD 기록
ord-b38039242dca4f84b22e92e360aecbe0
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599333

연결된 노트

불러오는 중…