Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → HCID 58386658, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 2-Bromoisonicotinic acid | HCID 222701 | — |
| 반응물 | Bms-973013 | HCID 22293182 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 58386658 | HCID 58386658 | — |
반응 단계
0.50 g (2.4 mmol) 2-bromopyridine-4-carboxylic acid and 1.1 g (5.0 mmol) 1-piperidin-4-yl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one were mixed and melted for 10 min using the hot air blower. The reaction mixture was cooled, mixed with water and made basic with ammonia. It was extracted with EtOAc. The aqueous phase was concentrated and purified by HPLC. The product-containing fractions were combined and concentrated to dryness by rotary evaporation.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-d9b8229d44f84c40bdf10d0071e87ef6 |
| 출처 메모 | uspto-grants-2014_09 |