Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 1-(3-(Benzoylthio)-2-methylpropanoyl)-2-indolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | (1)-S-(3-Chloro-2-methyl-3-oxopropyl) benzenecarbothioate | HCID 12878433 | — |
| 반응물 | Indoline-2-carboxylic acid hydrochloride | HCID 67437533 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-(3-(Benzoylthio)-2-methylpropanoyl)-2-indolinecarboxylic acid | HCID 494323 | — |
반응 단계
To the mixture of 5.0 g of indoline-2-carboxylic acid hydrochloride and 50 ml of methylene chloride are added 7.9 g of triethylamine, and after 5 minutes 6.1 g of 3-benzoylthio-2-methylpropanoyl chloride during 3 minutes. After stirring the mixture at room temperature for 2 hours, it is extracted thrice with 50 ml of saturated aqueous sodium bicarbonate. The combined aqueous solutions are adjusted to pH=1 with 4N hydrochloric acid and reextracted thrice with 50 ml of methylene chloride. The combined extracts are dried and evaporated, to yield the 1-(3-benzoylthio-2-methylpropanoyl)-indoline-2-carboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04599357 |
| 출처 데이터셋 | uspto-grants-1986_07 |
| ORD ID | ord-1ac35ae9687440148a1c29ef257f62a7 |
| 출처 메모 | uspto-grants-1986_07 |