Ammonia → HCID 2755910, 화합물
반응식
Cl.[CH3:2][C:3]1([CH3:17])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]1[C:12](OCC)=[O:13].[NH3:18]>C(O)C>[CH3:2][C:3]1([CH3:17])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]1[C:12]([NH2:18])=[O:13]참가 물질
4
실험 절차
The solution of 1 g of ethyl 3,3-dimethylindoline-2-carboxylate hydrochloride in 25 ml of ethanol is saturated with anhydrous ammonia and heated in a closed vessel to 50° for 4 days. It is evaporated, the residue crystallized from diethyl ether, suspended in water and 3N aqueous sodium hydroxide is added to render the mixture basic. It is extracted with methylene chloride, the extract dried and evaporated, to yield the 3,3-dimethylindoline-2-carboxamide melting at 156°-158°.
후처리
- temperatureheated in a closed vessel to 50° for 4 days
- customIt is evaporated
- customthe residue crystallized from diethyl ether
- addition3N aqueous sodium hydroxide is added to render the mixture basic
- extractionIt is extracted with methylene chloride
- customthe extract dried
- customevaporated
출처 및 근거
- ORD 기록
- ord-1da7de8daefb403ca813120d7debada6
- 출처 데이터셋
- uspto-grants-1986_07
- 특허 번호
- US04599357
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