Carnitine Chloride → Norcarnitine

HRID 745675

반응식

HRID 745675 반응식
[CH3:1][N+:2]([CH2:5][CH:6]([OH:11])[CH2:7][C:8]([OH:10])=[O:9])(C)[CH3:3].[Cl-].N12CCN(CC1)CC2>CN(C=O)C>[CH3:1][N:2]([CH2:5][C@H:6]([OH:11])[CH2:7][C:8]([OH:10])=[O:9])[CH3:3]

참가 물질

4

반응물 2

HCID 5970Carnitine ChlorideHCID 9237Dabco

생성물 1

HCID 3081992Norcarnitine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
125 °C

실험 절차

L-carnitine chloride (1.5. g; 0.008 moles) and 1,4 diazabicyclo[2,2,2]octane (5.25 g; 0.05 moles) were dissolved in 50 cc of DMF at 80° C. The resulting solution was subsequently heated up to 125° C. for 2 hours. Upon reaction termination, the solution was cooled in an ice bath a 5° C. After about 2 hours the precipitate which formed consisting of the excess diazabicyclo octane and its N-methyl derivative was filtered off. DMF was distilled under vacuum and the residue dissolved in water and eluted on AMBERLITE IRA 402 resin activated in the OH-l form. The eluate having alkaline pH was shown to consist of diazabicyclo octane and its N-methyl derivative; L-norcarnitine which formed was retained on the resin and was eluted therefrom with 2N HCl.

후처리

  1. customUpon reaction termination
  2. temperaturethe solution was cooled in an ice bath a 5° C
  3. customAfter about 2 hours the precipitate which formed
  4. filtrationwas filtered off
  5. distillationDMF was distilled under vacuum
  6. dissolutionthe residue dissolved in water
  7. washeluted on AMBERLITE IRA 402 resin

출처 및 근거

ORD 기록
ord-4b7a83338cdf4bc8aacd50edcdfc5d19
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04599447

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