Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate → methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate | HCID 10243182 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl (4-amino-2,3-dihydro-1H-indol-3-yl)acetate | HCID 10104433 | — |
반응 단계
2.0 g (8.5 mmol) methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate in 70 mL MeOH were combined with 0.30 g Raney nickel and hydrogenated for 2 h in a hydrogen atmosphere. The catalyst was removed by suction filtering and the solution was concentrated by rotary evaporation. The residue was immediately reacted further without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829006B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-5ff40530b07748d5b45375c1bd584cf4 |
| 출처 메모 | uspto-grants-2014_09 |