methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate → HCID 10104433, 화합물

HRID 74573

반응식

HRID 74573 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2)([O-])=O.[H][H]>CO.[Ni]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7][NH:8]2

참가 물질

5

반응물 2

HCID 10243182methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 10104433HCID 10104433, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

2.0 g (8.5 mmol) methyl (4-nitro-2,3-dihydro-1H-indol-3-yl)-acetate in 70 mL MeOH were combined with 0.30 g Raney nickel and hydrogenated for 2 h in a hydrogen atmosphere. The catalyst was removed by suction filtering and the solution was concentrated by rotary evaporation. The residue was immediately reacted further without further purification.

후처리

  1. customThe catalyst was removed by suction
  2. filtrationfiltering
  3. concentrationthe solution was concentrated by rotary evaporation
  4. customThe residue was immediately reacted further without further purification

출처 및 근거

ORD 기록
ord-5ff40530b07748d5b45375c1bd584cf4
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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