Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 5-(4-Bromophenylsulphonyl)-6-methyl-1,3-benzodioxole-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Dibromoacetic Acid | HCID 12433 | — |
| 반응물 | 4-(4-Bromophenylsulphonyl)-5-methyl-1,2-benzenediol | HCID 23312109 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-(4-Bromophenylsulphonyl)-6-methyl-1,3-benzodioxole-2-carboxylic acid | HCID 23312131 | — |
반응 단계
In a manner analogous to that described in Example 15, 60.0 g of 4-(4-bromophenylsulphonyl)-5-methyl-1,2-benzenediol are reacted in the presence of 120 g of potassium carbonate in 300 ml of dimethylformamide with a solution of 76.2 g of dibromoacetic acid in 100 ml of dimethylformamide. After working up and chromatographic purification in a manner analogous to that described in Example 15 and crystallisation from 1,2-dichloroethane, 5-(4-bromophenylsulphonyl)-6-methyl-1,3-benzodioxole-2-carboxylic acid is obtained in the form of sand-coloured crystals having a melting point of 170°-172.5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04600709 |
| 출처 데이터셋 | uspto-grants-1986_07 |
| ORD ID | ord-cbf23a6c952845489fcf099f6f664760 |
| 출처 메모 | uspto-grants-1986_07 |