4-Chloropyridine-2-carboxylic acid → HCID 58386653, 화합물

HRID 74582

반응식

HRID 74582 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=O)[CH:3]=1.[F:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[NH:17][CH2:16][C:15]2([CH3:22])[CH3:21].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([N:17]2[C:18]3[C:14](=[CH:13][C:12]([F:11])=[CH:20][CH:19]=3)[C:15]([CH3:22])([CH3:21])[CH2:16]2)=[O:10])[CH:3]=1

참가 물질

5

반응물 3

HCID 2308904-Chloropyridine-2-carboxylic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 21712575HCID 21712575, 화합물

생성물 1

HCID 58386653HCID 58386653, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.17 g (1.1 mmol) 4-chloro-pyridine-2-carboxylic acid, 0.18 g (1.1 mmol) 5-fluoro-3,3-dimethyl-2,3-dihydro-1H-indole, 0.28 mL (2.0 mmol) TEA and 3.0 mL DMF were combined with 0.39 g (1.2 mmol) TBTU and stirred overnight at RT. The reaction mixture was purified by HPLC. The product fractions were combined and evaporated down.

후처리

  1. customThe reaction mixture was purified by HPLC
  2. customevaporated down

출처 및 근거

ORD 기록
ord-9a0703c2e67a45d0a715f72ec86fc841
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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