Trichloroacetyl isocyanate → HCID 14556140, 화합물

HRID 745967노트

반응식

HRID 745967 반응식
[Cl:1][C:2]([Cl:9])([Cl:8])[C:3]([N:5]=[C:6]=[O:7])=[O:4].[OH:10][CH2:11][C:12]1[CH2:13][S:14][C@@H:15]2[C@H:22]([NH:23][C:24](=[O:31])[CH2:25][C:26]3[S:27][CH:28]=[CH:29][CH:30]=3)[C:21](=[O:32])[N:16]2[C:17]=1[C:18]([OH:20])=[O:19]>C(OCC)(=O)C>[S:27]1[CH:28]=[CH:29][CH:30]=[C:26]1[CH2:25][C:24]([NH:23][C@@H:22]1[C:21](=[O:32])[N:16]2[C:17]([C:18]([OH:20])=[O:19])=[C:12]([CH2:11][O:10][C:6](=[O:7])[NH:5][C:3](=[O:4])[C:2]([Cl:9])([Cl:8])[Cl:1])[CH2:13][S:14][C@H:15]12)=[O:31]

참가 물질

4

반응물 2

HCID 76400Trichloroacetyl isocyanateHCID 93015Deacetylcephalothin

생성물 1

HCID 14556140HCID 14556140, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Trichloroacetylisocyanate (4.3 ml) was added rapidly to a stirred suspension of (6R,7R)-3-hydroxymethyl-7-(2-thienylacetamido)ceph-3-em-4-carboxylic acid (10.62 g) at 6° in ethyl acetate (70 ml). The reaction mixture was stirred at 5° for 40 min. Petroleum ether was added dropwise during 15 min. The mixture was stirred for 30 min, filtered and the solid was washed with petroleum ether and dried to give the title compound as a solid (16.48 g), [α]D22 +73° (c 1.2 in Me2SO).

후처리

  1. stirringThe mixture was stirred for 30 min
  2. filtrationfiltered
  3. washthe solid was washed with petroleum ether
  4. customdried

출처 및 근거

ORD 기록
ord-b961cb4450504efd8ca8a78f04f61b05
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04602012

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