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Water → (5-Bromo-4-chloro-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone

HRID 74598
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인쇄 미리보기

반응식

HRID 74598 반응식
CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.[Br:23][C:24]1[C:25]([Cl:33])=[CH:26][C:27]([C:30]([OH:32])=O)=[N:28][CH:29]=1.[F:34][C:35]1[CH:36]=[C:37]2[C:41](=[CH:42][CH:43]=1)[NH:40][CH2:39][CH2:38]2.O>CN(C=O)C>[Br:23][C:24]1[C:25]([Cl:33])=[CH:26][C:27]([C:30]([N:40]2[C:41]3[C:37](=[CH:36][C:35]([F:34])=[CH:43][CH:42]=3)[CH2:38][CH2:39]2)=[O:32])=[N:28][CH:29]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 27744635-FluoroindolineHCID 583866545-Bromo-4-chloropyridine-2-carboxylic acid

생성물 1

HCID 58386444(5-Bromo-4-chloro-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

0.75 mg (2.3 mmol) TBTU were added to 0.50 g (2.1 mmol) 5-bromo-4-chloro-pyridine-2-carboxylic acid, 0.29 g (2.1 mmol) 5-fluoro-2,3-dihydro-1H-indole and 0.62 mL (4.4 mmol) TEA in 11 mL DMF and the mixture was stirred overnight at RT. Then the reaction mixture was combined with water, the precipitate formed was suction filtered and dried.

후처리

  1. customthe precipitate formed
  2. filtrationfiltered
  3. customdried

출처 및 근거

ORD 기록
ord-ca0196b21ea7422b95abf6325bf9cc88
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08829006B2

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