Potassium Carbonate → HCID 58386754, 화합물

HRID 74608

반응식

HRID 74608 반응식
Cl[C:2]1[C:7]([I:8])=[CH:6][N:5]=[C:4]([C:9]([N:11]2[C:19]3[C:14](=[CH:15][C:16]([F:20])=[CH:17][CH:18]=3)[CH2:13][CH2:12]2)=[O:10])[CH:3]=1.[NH:21]1[CH2:26][CH2:25][CH:24]([N:27]2[C:35]3[C:30](=[N:31][CH:32]=[CH:33][CH:34]=3)[NH:29][C:28]2=[O:36])[CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+].CN1C(=O)CCC1>O>[F:20][C:16]1[CH:15]=[C:14]2[C:19](=[CH:18][CH:17]=1)[N:11]([C:9]([C:4]1[CH:3]=[C:2]([N:21]3[CH2:22][CH2:23][CH:24]([N:27]4[C:35]5[C:30](=[N:31][CH:32]=[CH:33][CH:34]=5)[NH:29][C:28]4=[O:36])[CH2:25][CH2:26]3)[C:7]([I:8])=[CH:6][N:5]=1)=[O:10])[CH2:12][CH2:13]2

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 22293182Bms-973013HCID 58386447HCID 58386447, 화합물

생성물 1

HCID 58386754HCID 58386754, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
130 °C

실험 절차

0.50 g (1.2 mmol) (4-chloro-5-iodo-pyridin-2-yl)-(5-fluoro-2,3-dihydro-indol-1-yl)-methanone, 0.27 g (1.2 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one, 0.26 g (1.9 mmol) potassium carbonate and 3.5 mL NMP were combined and stirred at 130° C. for 10 h. After the addition of water the precipitate formed was suction filtered and dried.

후처리

  1. customformed
  2. filtrationfiltered
  3. customdried

출처 및 근거

ORD 기록
ord-b63fd310b142457785fcb6a977ebc1de
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829006B2

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