Ethanol → HCID 20240708, 화합물

HRID 746115노트

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HRID 746115 반응식
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]([C:11]([O:13]CC)=O)[C:6](=[O:7])[N:5]([CH3:16])[C:3]1=[O:4].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[CH:21][C:22]([O:25][C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)=[N:23][CH:24]=1.C(O)C>C1(C)C=CC=CC=1>[CH3:16][N:5]1[C:6](=[O:7])[CH:8]([C:11](=[O:13])[NH:30][C:29]2[CH:31]=[CH:32][C:26]([O:25][C:22]3[CH:21]=[CH:20][C:19]([C:18]([F:34])([F:17])[F:33])=[CH:24][N:23]=3)=[CH:27][CH:28]=2)[C:9](=[O:10])[N:2]([CH3:1])[C:3]1=[O:4]

참가 물질

5

반응물 3

HCID 702EthanolHCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 27830854-{[5-(Trifluoromethyl)pyridin-2-yl]oxy}aniline

생성물 1

HCID 20240708HCID 20240708, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

1.60 g (0.007 mol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid and 1.78 g (0.007 mol) of 4-(5-trifluoromethylpyrid-2-yloxy)aniline are suspended in 20 ml of toluene. The suspension is heated to reflux for 16 hours, during which time ethanol escapes. After cooling, the precipitate is isolated by filtration, washed with toluene and dried, affording 1,3-dimethyl-5-[4-(5-trifluoromethylpyrid-2-yloxy)phenylcarbamoyl]barbituric acid of the formula ##STR24## with a melting point of 180°-181° C.

후처리

  1. temperatureThe suspension is heated
  2. temperatureAfter cooling
  3. customthe precipitate is isolated by filtration
  4. washwashed with toluene
  5. customdried

출처 및 근거

ORD 기록
ord-ad9e6b3518fe46199102c704e4503b77
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04602912

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