Thionyl Chloride → 2-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

HRID 746134노트

반응식

HRID 746134 반응식
[Cl:1][C:2]1[S:3][C:4]([C:11]([O:13]CC)=O)=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[S:3][C:4]([C:11]([Cl:18])=[O:13])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 1235240Ethyl 2-chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate

생성물 1

HCID 132827442-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

실험 절차

A mixture of 36.0 g (0.1554 mole) of the acid of Example 17 and 171 g (1.437 mole) of thionyl chloride were held at reflux for 6 hours. Excess thionyl chloride was removed under reduced pressure and the residue (38.1 g, 98%) was reacted as described in Examples 19-31.

후처리

  1. temperatureat reflux for 6 hours
  2. customExcess thionyl chloride was removed under reduced pressure
  3. customthe residue (38.1 g, 98%) was reacted

출처 및 근거

ORD 기록
ord-a0f61152d1384babb9cba12f7a5cd96a
출처 데이터셋
uspto-grants-1986_07
특허 번호
US04602937

반응 노트

불러오는 중…